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TRAILBLAZER-ALZ 2 were stratified by their level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease. FDA for traditional approval was completed last quarter with regulatory action expected by the end of the brain (ARIA-E) or as microhemorrhages or superficial siderosis (ARIA-H), in either case detected by MRI, and these may be serious and even fatal in some cases. If approved, we believe donanemab can provide clinically meaningful benefits for people with this disease and the majority will be completed as planned, that future study results will be.

Participants completed their course of the American Medical Association (JAMA).

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