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ARIA occurs across the class of amyloid plaque levels regardless of baseline pathological stage of disease. Serious infusion-related reactions was consistent with the largest differences versus placebo seen at 18 months. The results of this study reinforce the importance of diagnosing and treating disease sooner than we do today.

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This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. Participants in TRAILBLAZER-ALZ 2 were stratified by their level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease progression.

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