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If approved, we believe donanemab can provide clinically meaningful benefits for people with this disease and the possibility of completing their course of treatment with donanemab once they achieved pre-defined criteria of amyloid plaque-targeting therapies. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the New England Journal of Medicine (NEJM) results from the Phase 3 study. This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected.
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