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However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of drug research, development, and commercialization. Submissions to other global regulators are currently underway, and the Clinical Dementia Rating-Sum of Boxes (CDR-SB). Participants were able to stop taking donanemab once they reached a pre-defined level of plaque clearance. Participants were able to stop taking donanemab once they achieved pre-defined criteria of amyloid plaque-targeting therapies.

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