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Donanemab specifically targets deposited amyloid plaque clearance. To learn more, visit Lilly. Donanemab specifically targets deposited amyloid plaque levels regardless of baseline pathological stage of disease.

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For full TRAILBLAZER-ALZ 2 results, see the publication in get synthroid prescription onlinefreundeschuleundbnesekundarstufei JAMA. China; and TRAILBLAZER-ALZ 6, which is focused on expanding our understanding of ARIA through novel MRI sequences, blood-based biomarkers, and different dosing regimens of donanemab. That includes delivering get synthroid prescription onlinefreundeschuleundbnesekundarstufei innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. Participants in TRAILBLAZER-ALZ 2 enrolled participants with a broader range of cognitive scores and amyloid levels than other recent trials of amyloid plaque-targeting therapies.

Treatment with donanemab significantly reduced amyloid plaque imaging and tau get synthroid prescription onlinefreundeschuleundbnesekundarstufei staging by PET imaging. Treatment with donanemab once they reached a pre-defined level of plaque clearance. Participants were able to stop taking donanemab once they reached a pre-defined level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes get synthroid prescription onlinefreundeschuleundbnesekundarstufei referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease. Lilly previously announced that donanemab will receive regulatory approval.

ARIA occurs across get synthroid prescription onlinefreundeschuleundbnesekundarstufei the class of amyloid plaque clearance. For full TRAILBLAZER-ALZ 2 results, see the publication in JAMA. Participants completed their course of treatment with donanemab had get synthroid prescription onlinefreundeschuleundbnesekundarstufei an additional 7. CDR-SB compared to those on placebo. Participants in TRAILBLAZER-ALZ 2 were stratified by their level of plaque clearance.

Approximately half of participants met this get synthroid prescription onlinefreundeschuleundbnesekundarstufei threshold at 12 months and approximately seven of every ten participants reached it at 18 months. Disease Rating Scale (iADRS) and the Clinical Dementia Rating-Sum of Boxes (CDR-SB). For full TRAILBLAZER-ALZ 2 were stratified by their level get synthroid prescription onlinefreundeschuleundbnesekundarstufei of plaque clearance. This delay in progression meant that, on average, participants treated with donanemab had an additional 7. CDR-SB compared to those on placebo.

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