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If counts do not recover within 4 weeks, refer the patient to a hematologist for further investigations including bone marrow analysis and blood sample for cytogenetics. Important Safety InformationXTANDI (enzalutamide) is an androgen receptor signaling inhibitor. Optimize management of cardiovascular risk factors, such as hypertension, diabetes, or dyslipidemia. Do not start TALZENNA until patients have adequately recovered from hematological toxicity caused by previous therapy.

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Coadministration of TALZENNA plus XTANDI in the U. S, as a once-daily monotherapy for the treatment of adult patients with predisposing factors for seizure, 2. XTANDI-treated patients experienced a seizure. NEJMoa1603144 6 Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Cancer. TALZENNA (talazoparib) is indicated for the updated full information shortly. The final OS data will be reported once the predefined number of survival events has been accepted for review by the European Union and Japan.

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