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No dose adjustment is required for patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC). Optimize management of cardiovascular risk factors, such as hypertension, diabetes, or dyslipidemia. TALZENNA (talazoparib) is indicated for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human where to buy vfend pills epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer.

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