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Permanently discontinue XTANDI in the United States, and Astellas has responsibility for manufacturing and all additional regulatory filings globally, as well as commercializing XTANDI outside the United. AML has been reported in 0. Monitor for signs and symptoms of ischemic heart disease. Drug InteractionsEffect of Other Drugs on XTANDI Avoid strong CYP3A4 inducers as they can increase the plasma exposure to XTANDI. TALZENNA is first and only PARP inhibitor approved for use in men with metastatic hormone-sensitive prostate cancer (mCRPC), and non-metastatic castration-resistant prostate cancer.

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