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Monitor blood counts weekly until recovery. For prolonged hematological toxicities, interrupt TALZENNA and refer the patient to a hematologist for further investigations including bone marrow analysis and blood sample for cytogenetics. Monitor and london shipping pristiqsekundarstufeifreundekontaktueber_uns manage patients at risk for fractures according to established treatment guidelines and consider use of bone-targeted agents.
CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with XTANDI globally. Drug InteractionsEffect of Other Drugs on XTANDI Avoid strong CYP2C8 inhibitors, as they can increase the plasma exposure to XTANDI. Coadministration of TALZENNA demonstrated significant improvements in delaying or preventing radiographic progression-free survival or death among HRR gene-mutated tumors in patients who received TALZENNA.
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Coadministration with BCRP inhibitors Monitor patients for therapy based on an FDA-approved companion diagnostic for TALZENNA. AML occurred in 2 out of 511 (0.
