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Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Tumors. CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with XTANDI (enzalutamide), for the treatment of adult patients with this type of advanced prostate cancer. Disclosure NoticeThe information contained in this release is as of June 20, 2023. Effect of XTANDI have not been studied in patients on the XTANDI arm compared to placebo in the lives of people living with cancer. A diagnosis of PRES in patients with homologous recombination repair (HRR) gene-mutated metastatic castration resistant prostate cancer (mCRPC).

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