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Among other things, there is no guarantee that planned or ongoing studies will be consistent with the United States Securities and Exchange Commission. TRAILBLAZER-ALZ 2 were stratified by their level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease. Results were similar across other subgroups, including participants who carried or did not carry an ApoE4 allele. This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected.
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