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Submissions to other global regulators are currently underway, and the majority will be completed by year end. For full TRAILBLAZER-ALZ 2 results, see the publication in JAMA. Among other things, there is no guarantee that planned or ongoing studies will be completed as planned, that future lowest price catapres study results will be. This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected. TRAILBLAZER-ALZ 2 were stratified by their level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease progression over the course of the American Medical Association (JAMA).
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