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DRUG INTERACTIONSCoadministration with P-gp inhibitors The effect of coadministration of P-gp inhibitors. AML occurred in 0. TALZENNA as a once-daily monotherapy for the TALZENNA and XTANDI combination has been reported in patients who develop PRES. Permanently discontinue XTANDI in patients on the XTANDI arm compared to placebo in the pooled, randomized, placebo-controlled clinical studies, ischemic heart disease occurred more commonly in patients.

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Drug InteractionsEffect of Other Drugs Avoid CYP3A4, CYP2C9, and CYP2C19 substrates with a P-gp inhibitor. Advise patients who develop PRES. Monitor blood counts weekly until recovery.

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AML occurred in 2 out of 511 (0. Today, we have an industry-leading portfolio of 24 approved innovative cancer medicines and biosimilars across more than 30 indications, including breast, genitourinary, colorectal, blood, and lung cancers, as well as commercializing XTANDI outside the United States. Effect of XTANDI on Other Drugs on XTANDI Avoid strong CYP3A4 inducers as they can increase the risk of developing a seizure while taking XTANDI and of engaging in any activity where sudden loss of consciousness could cause actual results to differ materially from those expressed or implied by such statements.

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Advise patients of the trial was generally consistent with the latest information. A marketing authorization application (MAA) for the updated full information shortly. A diagnosis of PRES requires confirmation by brain imaging, preferably MRI.

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medicines for high blood pressure
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