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Participants were able to stop taking donanemab once they reached a pre-defined level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease. Results were similar across other subgroups, including participants who carried or did not carry an ApoE4 allele. Participants were able to stop taking donanemab once they achieved pre-defined criteria of amyloid plaque-targeting therapies.

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