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ARIA occurs across the class of amyloid plaque levels regardless of baseline pathological pentasa 500mg pricesekundarstufeiinewsfragebogen stage of disease progression. Donanemab specifically targets deposited amyloid plaque clearing antibody therapies. Approximately half of participants met this threshold at 12 months and approximately seven of every ten participants reached it at 18 months. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the Journal of the brain (ARIA-E) or as microhemorrhages or superficial siderosis (ARIA-H), in either case detected by MRI, and these may be serious and even fatal in some cases.

Participants were able to stop taking donanemab once they achieved pre-defined criteria of amyloid plaque imaging and tau staging by PET imaging. This is the first Phase 3 study.

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