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Participants were able to stop taking donanemab once they reached a pre-defined level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease. Among other things, there is no guarantee that planned or ongoing studies will be completed as planned, that future study results will be. This delay in progression meant that, on average, participants treated with donanemab had an additional 7. CDR-SB compared to those on placebo.

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