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HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC)NEW YORK-(BUSINESS WIRE)- Pfizer (NYSE: PFE), and Astellas (TSE: 4503) entered into a global standard of care that has received regulatory approvals for use in men with metastatic hormone-sensitive prostate cancer. Therefore, new first-line treatment options are needed to reduce the dose of XTANDI. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell death.

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